Berkeley Pit: The Stierles’ Research

Research

Here is a small sampling of Drs. Andrea and Don Stierle’s research.

  • A fungus from the Berkeley Pit produced several compounds that were cytotoxic toward certain leukemia and melanoma cell lines. Click here to learn more.
  • Microbes in the Berkeley Pit have adapted to survive in conditions that are similar to inflamed mammalian cells, so the metabolites produced have been shown to treat inflammation related to numerous human diseases. Click here to learn more.
  • A fungi was isolated from a green alga in the Pit. In culture it produced several known compounds which are potent inhibitors of specific and established human cancer cell lines. Click here to learn more.
  • Several metabolites were isolated from a culture broth of a Penicillium taken from a depth of 270 m. Certain Berkeley Pit compounds exhibited selective activity against leukemia cancer cell lines in the National Cancer Institute 60 human cell line assay. Click here to learn more.
  • Berkelic acid has shown selective activity against OVCAR-3, an ovarian cancer cell line in the National Cancer Institute cell line screen. Click here to learn more.
  • Two novel hybrid metabolites were isolated from a Penicillium sp. growing in the Berkeley Pit Lake of Butte, Montana. Both compounds showed activity toward non-small-cell lung cancer in NCI’s human cell line antitumor screen. Click here to learn more.

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